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1 November 2008 Promotion of Initiated Cells by Radiation-Induced Cell Inactivation
W. F. Heidenreich, H. G. Paretzke
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Heidenreich, W. F. and Paretzke, H. G. Promotion of Initiated Cells by Radiation-Induced Cell Inactivation. Radiat. Res. 170, 613–617 (2008).

Cells on the way to carcinogenesis can have a growth advantage relative to normal cells. It has been hypothesized that a radiation-induced growth advantage of these initiated cells might be induced by an increased cell replacement probability of initiated cells after inactivation of neighboring cells by radiation. Here Monte Carlo simulations extend this hypothesis for larger clones: The effective clonal expansion rate decreases with clone size. This effect is stronger for the two-dimensional than for the three-dimensional situation. The clones are irregular, far from a circular shape. An exposure-rate dependence of the effective clonal expansion rate could come in part from a minimal recovery time of the initiated cells for symmetric cell division.

W. F. Heidenreich and H. G. Paretzke "Promotion of Initiated Cells by Radiation-Induced Cell Inactivation," Radiation Research 170(5), 613-617, (1 November 2008).
Received: 11 January 2007; Accepted: 1 June 2008; Published: 1 November 2008

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