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1 December 2008 Effects of GSM-Modulated Radiofrequency Electromagnetic Fields on Mouse Bone Marrow Cells
Maria Grazia Prisco, Francesca Nasta, Maria Manuela Rosado, Giorgio Alfonso Lovisolo, Carmela Marino, Claudio Pioli
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Abstract

Prisco, M. G., Nasta, F., Rosado, M. M., Lovisolo, G. A., Marino, C. and Pioli, C. Effects of GSM-Modulated Radiofrequency Electromagnetic Fields on Mouse Bone Marrow Cells. Radiat. Res. 170, 803–810 (2008).

We examined the effects of in vivo exposure to a GSM-modulated 900 MHz RF field on the ability of bone marrow cells to differentiate, colonize lymphatic organs, and rescue lethally X-irradiated mice from death. X-irradiated mice were injected with medium alone or containing bone marrow cells from either RF-field-exposed (SAR 2 W/kg, 2 h/day, 5 days/ week, 4 weeks) or sham-exposed or cage control donor mice. Whereas all mice injected with medium alone died, mice that received bone marrow cells survived. Three and 6 weeks after bone marrow cell transplantation, no differences in thymus cellularity and in the frequencies of differentiating cell subpopulations (identified by CD4/CD8 expression) were observed among the three transplanted groups. Mitogen-induced thymocyte proliferation yielded comparable levels in all transplanted groups. As to the spleen, no effects of the RF-field exposure on cell number, percentages of B and T (CD4 and CD8) cells, B- and T-cell proliferation, and IFN-γ production were found in transplanted mice. In conclusion, our results show no effect of in vivo exposure to GSM-modulated RF fields on the ability of bone marrow precursor cells to home and colonize lymphoid organs and differentiate in phenotypically and functionally mature T and B lymphocytes.

Maria Grazia Prisco, Francesca Nasta, Maria Manuela Rosado, Giorgio Alfonso Lovisolo, Carmela Marino, and Claudio Pioli "Effects of GSM-Modulated Radiofrequency Electromagnetic Fields on Mouse Bone Marrow Cells," Radiation Research 170(6), 803-810, (1 December 2008). https://doi.org/10.1667/RR1213.1
Received: 11 September 2007; Accepted: 1 July 2008; Published: 1 December 2008
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