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1 August 2009 Protective Effects of Dietary Antioxidants on Proton Total-Body Irradiation-Mediated Hematopoietic Cell and Animal Survival
Chris O. Wambi, Jenine K. Sanzari, Carly M. Sayers, Manunya Nuth, Zhaozong Zhou, James Davis, Niklas Finnberg, Joan S. Lewis-Wambi, Jeffrey H. Ware, Wafik S. El-Deiry, Ann R. Kennedy
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Abstract

Dietary antioxidants have radioprotective effects after γ-radiation exposure that limit hematopoietic cell depletion and improve animal survival. The purpose of this study was to determine whether a dietary supplement consisting of l-selenomethionine, vitamin C, vitamin E succinate, α-lipoic acid and N-acetyl cysteine could improve survival of mice after proton total-body irradiation (TBI). Antioxidants significantly increased 30-day survival of mice only when given after irradiation at a dose less than the calculated LD50/30; for these data, the dose-modifying factor (DMF) was 1.6. Pretreatment of animals with antioxidants resulted in significantly higher serum total white blood cell, polymorphonuclear cell and lymphocyte cell counts at 4 h after 1 Gy but not 7.2 Gy proton TBI. Antioxidants significantly modulated plasma levels of the hematopoietic cytokines Flt-3L and TGFβ1 and increased bone marrow cell counts and spleen mass after TBI. Maintenance of the antioxidant diet resulted in improved recovery of peripheral leukocytes and platelets after sublethal and potentially lethal TBI. Taken together, oral supplementation with antioxidants appears to be an effective approach for radioprotection of hematopoietic cells and improvement of animal survival after proton TBI.

Chris O. Wambi, Jenine K. Sanzari, Carly M. Sayers, Manunya Nuth, Zhaozong Zhou, James Davis, Niklas Finnberg, Joan S. Lewis-Wambi, Jeffrey H. Ware, Wafik S. El-Deiry, and Ann R. Kennedy "Protective Effects of Dietary Antioxidants on Proton Total-Body Irradiation-Mediated Hematopoietic Cell and Animal Survival," Radiation Research 172(2), 175-186, (1 August 2009). https://doi.org/10.1667/RR1708.1
Received: 26 December 2008; Accepted: 1 March 2009; Published: 1 August 2009
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