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8 January 2010 Carcinogenic Interactions between a Single Inhalation of 239PuO2 and Chronic Exposure to Cigarette Smoke in Rats
Joe L. Mauderly, Steven K. Seilkop, Edward B. Barr, Andrew P. Gigliotti, Fletcher F. Hahn, Charles H. Hobbs, Gregory L. Finch
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Abstract

Rats were exposed once by inhalation to plutonium-239 dioxide (239PuO2), resulting in chronic α-particle irradiation of the lung, and exposed chronically to cigarette smoke to examine carcinogenic interactions between the two exposures. F344 rats were exposed to 239PuO2 to achieve an initial lung burden of 0.5 kBq and then exposed 6 h/day, 5 days/week to cigarette smoke at 100 or 250 mg particulate matter/m3 for up to 30 months. Exposure to cigarette smoke increased the cumulative radiation dose to lung by slowing the clearance of 239PuO2. 239PuO2 alone did not affect survival, but the higher cigarette smoke exposure shortened survival in females. Combined exposure to 239PuO2 and cigarette smoke acted synergistically to shorten survival in both genders. The combined effects of cigarette smoke and 239PuO2 were approximately additive for lung hyperplasia and adenomas but were strongly synergistic for carcinomas. Differences between observed incidences and incidences predicted by survival-adjusted models accounting for increased radiation dose revealed a substantial component of synergy for carcinomas above that attributable to the radiation dose effect. The synergy for malignant lung tumors is consistent with findings from uranium miners and nuclear weapons production workers. These results bolster confidence in the epidemiological findings and have implications for risk assessment.

Joe L. Mauderly, Steven K. Seilkop, Edward B. Barr, Andrew P. Gigliotti, Fletcher F. Hahn, Charles H. Hobbs, and Gregory L. Finch "Carcinogenic Interactions between a Single Inhalation of 239PuO2 and Chronic Exposure to Cigarette Smoke in Rats," Radiation Research 173(5), 665-676, (8 January 2010). https://doi.org/10.1667/RR1907.1
Received: 23 June 2009; Accepted: 1 November 2009; Published: 8 January 2010
JOURNAL ARTICLE
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