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9 March 2011 Terahertz Radiation Induces Spindle Disturbances in Human-Hamster Hybrid Cells
H. Hintzsche, C. Jastrow, T. Kleine-Ostmann, H. Stopper, E. Schmid, T. Schrader
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Abstract

The aim of this study was to investigate and quantify the production of spindle disturbances in AL cells, a human-hamster hybrid cell line, by 0.106 THz radiation (continuous wave). Monolayer cultures in petri dishes were exposed for 0.5 h to 0.106 THz radiation with power densities ranging from 0.043 mW/cm2 to 4.3 mW/cm2 or were kept under sham conditions (negative control) for the same period. As a positive control, 100 µg/ml of the insecticide trichlorfon, which is an aneuploidy-inducing agent, was used for an exposure period of 6 h. During exposure, the sample containers were kept at defined environmental conditions in a modified incubator as required by the cells. Based on a total of 6,365 analyzed mitotic cells, the results of two replicate experiments suggest that 0.106 THz radiation is a spindle-acting agent as predominately indicated by the appearance of spindle disturbances at the anaphase and telophase (especially lagging and non-disjunction of single chromosomes) of cell divisions. The findings in the present study do not necessarily imply disease or injury but may be important for evaluating possible underlying mechanisms.

H. Hintzsche, C. Jastrow, T. Kleine-Ostmann, H. Stopper, E. Schmid, and T. Schrader "Terahertz Radiation Induces Spindle Disturbances in Human-Hamster Hybrid Cells," Radiation Research 175(5), 569-574, (9 March 2011). https://doi.org/10.1667/RR2406.1
Received: 10 August 2010; Accepted: 1 January 2011; Published: 9 March 2011
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