Translator Disclaimer
3 November 2011 The In Vivo Expression of Radiation-Induced Chromosomal Instability Has an Inflammatory Mechanism
Debayan Mukherjee, Philip J. Coates, Sally A. Lorimore, Eric G. Wright
Author Affiliations +
Abstract

Ionizing radiation is unequivocally leukemogenic and carcinogenic, and this is generally attributed to DNA damage arising as a consequence of deposition of energy in the cell nucleus at the time of exposure. However, nontargeted effects, in which DNA damage is produced in nonirradiated cells as a consequence of cell signaling processes, indicate additional mechanisms. Radiation-induced chromosomal instability, a nontargeted effect with the potential to produce pathological consequences, is characterized by an increased rate of chromosome aberrations many generations after the initial insult. In this study, using a mouse model that has been well characterized with respect to its susceptibility to both radiation-induced chromosomal instability and acute myeloid leukemia, we investigated whether the underlying signaling mechanism was an inflammatory process by studying the effects of a nonsteroidal anti-inflammatory drug. Treated mice showed significant reduction in expression of the chromosomal instability phenotype 100 days postirradiation associated with reduced expression of inflammatory markers. The data support the hypothesis that the radiation-induced chromosomal instability phenotype is not an intrinsic property of the cells but a consequence of inflammatory processes having the potential to contribute secondary damage expressed as nontargeted and delayed radiation effects.

Debayan Mukherjee, Philip J. Coates, Sally A. Lorimore, and Eric G. Wright "The In Vivo Expression of Radiation-Induced Chromosomal Instability Has an Inflammatory Mechanism," Radiation Research 177(1), 18-24, (3 November 2011). https://doi.org/10.1667/RR2793.1
Received: 6 September 2011; Accepted: 1 October 2011; Published: 3 November 2011
JOURNAL ARTICLE
7 PAGES


Share
SHARE
RIGHTS & PERMISSIONS
Get copyright permission
Back to Top