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8 March 2012 Magnetic Resonance Spectroscopy of Cancer Metabolism and Response to Therapy
Dominick J. O. McIntyre, Basetti Madhu, Shen-Han Lee, John R. Griffiths
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Abstract

Magnetic resonance spectroscopy allows noninvasive in vivo measurements of biochemical information from living systems, ranging from cultured cells through experimental animals to humans. Studies of biopsies or extracts offer deeper insights by detecting more metabolites and resolving metabolites that cannot be distinguished in vivo. The pharmacokinetics of certain drugs, especially fluorinated drugs, can be directly measured in vivo. This review briefly describes these methods and their applications to cancer metabolism, including glycolysis, hypoxia, bioenergetics, tumor pH, and tumor responses to radiotherapy and chemotherapy.

Dominick J. O. McIntyre, Basetti Madhu, Shen-Han Lee, and John R. Griffiths "Magnetic Resonance Spectroscopy of Cancer Metabolism and Response to Therapy," Radiation Research 177(4), 398-435, (8 March 2012). https://doi.org/10.1667/RR2903.1
Received: 14 December 2011; Accepted: 1 February 2012; Published: 8 March 2012
JOURNAL ARTICLE
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