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21 February 2012 Imaging Molecular Pathways: Reporter Genes
John Brogan, Fang Li, Wenrong Li, Zhimin He, Qian Huang, Chuan-Yuan Li
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Molecular imaging is a rapidly advancing field that allows cancer biologists to look deeper into the complex inner workings of tumor cells, or whole tumors, in a non-invasive manner. In this review, we will summarize some recent advances that enable investigators to study various important biological processes in tumors in vivo. We will discuss novel imaging approaches that allow investigators to visualize and quantify molecular pathways, such as receptor tyrosine kinase activation, hypoxia signal transduction, apoptosis, and DNA double-strand breaks. Select examples of these applications will be discussed. Because of the limited scope of this review, we will only focus on natural reporters, such as bioluminescence and fluorescent proteins.

John Brogan, Fang Li, Wenrong Li, Zhimin He, Qian Huang, and Chuan-Yuan Li "Imaging Molecular Pathways: Reporter Genes," Radiation Research 177(4), 508-513, (21 February 2012).
Received: 27 December 2011; Accepted: 1 January 2012; Published: 21 February 2012

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