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1 September 2012 A Focused Scanning Vertical Beam for Charged Particle Irradiation of Living Cells with Single Counted Particles
Michael J. Merchant, Jonathan C. G. Jeynes, Geoffrey W. Grime, Vladimir Palitsin, Iain D. W. Tullis, Paul R. Barber, Boris Vojnovic, Roger P. Webb, Karen J. Kirkby
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Abstract

The Surrey vertical beam is a new facility for targeted irradiation of cells in medium with singly counted ions. A duo-plasmatron ion source and a 2 MV Tandem™ accelerator supply a range of ions from protons to calcium for this beamline and microscope endstation, with energy ranges from 0.5 to 12 MeV. A magnetic quadrupole triplet lens is used to focus the beam of ions. We present the design of this beamline, and early results showing the capability to count single ions with 98% certainty on CR-39 track etch. We also show that the beam targeting accuracy is within 5 μm and selectively target human fibroblasts with a <5 μm carbon beam, using γ-H2AX immunofluorescence to demonstrate which cell nuclei were irradiated. We discuss future commissioning steps necessary to achieve submicron targeting accuracy with this beamline.

Michael J. Merchant, Jonathan C. G. Jeynes, Geoffrey W. Grime, Vladimir Palitsin, Iain D. W. Tullis, Paul R. Barber, Boris Vojnovic, Roger P. Webb, and Karen J. Kirkby "A Focused Scanning Vertical Beam for Charged Particle Irradiation of Living Cells with Single Counted Particles," Radiation Research 178(3), 182-190, (1 September 2012). https://doi.org/10.1667/RR2847.1
Received: 27 October 2011; Accepted: 1 February 2012; Published: 1 September 2012
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