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13 April 2018 Dose-Modifying Factor of Radiation Therapy with Concurrent Cisplatin Treatment in HPV-Positive Squamous Cell Carcinoma: A Preclinical Study
Ajda Prevc, Simona Kranjc, Maja Cemazar, Vesna Todorovic, Bojana Zegura, Matjaz Novak, Metka Filipic, Margareta Strojan Flezar, Irena Srebotnik Kirbis, Ana Rotter, Andreja Brozic, Martina Niksic Zakelj, Mario Poljak, Lea Hosnjak, Blaz Groselj, Primoz Strojan, Gregor Sersa
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Abstract

Human papillomavirus (HPV) is an important etiological factor in oropharyngeal squamous cell carcinoma (SCC). Compared to HPV-negative tumors, HPV-positive oropharyngeal SCC has shown a better response to nonsurgical treatments. In this study, we determined the dose-modifying factors for HPV-positive tumors with single-dose irradiation, with or without low radiosensitizing doses of cisplatin.In vitro, we determined an increased radiosensitivity of HPV-positive SCC, which might be a consequence of HPV-induced changes in the cell cycle regulation and DNA damage response, leading to increased cell death. Additionally, compared to HPV-negative tumors, 30% higher radiosensitivity of HPV-positive tumors was determined by tumor growth delay monitoring in immunodeficient mice in vivo. Concurrent cisplatin treatment had an additive effect in both HPV-negative and HPV-positive tumors, resulting in 20% better response in HPV-positive tumors than in HPV-negative tumors.

©2018 by Radiation Research Society.
Ajda Prevc, Simona Kranjc, Maja Cemazar, Vesna Todorovic, Bojana Zegura, Matjaz Novak, Metka Filipic, Margareta Strojan Flezar, Irena Srebotnik Kirbis, Ana Rotter, Andreja Brozic, Martina Niksic Zakelj, Mario Poljak, Lea Hosnjak, Blaz Groselj, Primoz Strojan, and Gregor Sersa "Dose-Modifying Factor of Radiation Therapy with Concurrent Cisplatin Treatment in HPV-Positive Squamous Cell Carcinoma: A Preclinical Study," Radiation Research 189(6), 644-651, (13 April 2018). https://doi.org/10.1667/RR14984.1
Received: 10 November 2017; Accepted: 1 March 2018; Published: 13 April 2018
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