Translator Disclaimer
14 July 2021 Biological Effective Dose for Treatment of a Heterogeneous Population of Cells with a Spread-Out Bragg Peak of Particle Radiation
Roland B. Hawkins
Author Affiliations +
Abstract

Calculation of the biological effective dose (BED) of a fractionated course of hadron particle radiation (e.g., protons or carbon ions) administered via a spread-out Bragg peak (SOBP) to a population of cells with heterogeneous radiosensitivity is described. The calculated BED has the important property that, if equal to that of a course of photon radiation, the particle course will result in the same fraction of cells of the exposed population that survive and can be expected to have the same clinical effect. The calculated BED provides a way to relate the effect of a planned treatment course with particle radiation to clinical experience of the effects of treatment with low-LET photon radiation.

©2021 by Radiation Research Society. All rights of reproduction in any form reserved.
Roland B. Hawkins "Biological Effective Dose for Treatment of a Heterogeneous Population of Cells with a Spread-Out Bragg Peak of Particle Radiation," Radiation Research 196(4), 386-393, (14 July 2021). https://doi.org/10.1667/RADE-20-00024.1
Received: 15 January 2020; Accepted: 21 December 2020; Published: 14 July 2021
JOURNAL ARTICLE
8 PAGES


Share
SHARE
RIGHTS & PERMISSIONS
Get copyright permission
Back to Top