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30 August 2021 Protective Effect of Sirt1 against Radiation-Induced Damage
Haoren Qin, Heng Zhang, Shiwu Zhang, Siwei Zhu, Hui Wang
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Radiotherapy is an important method for the treatment of malignant tumors. It can directly or indirectly lead to the formation of free radicals and DNA damage, resulting in a series of biological effects, including tumor cell death and normal tissue damage. These radiation effects are typically accompanied by the abnormal expression of sirtuin 1 (Sirt1), which deacetylates histones and non-histones. These Sirt1 substrates, including transcription factors and some catalytic enzymes, play a crucial role in anti-oxidative stress, DNA damage repair, autophagy regulation, anti-senescence, and apoptosis, which are closely related to triggering cell defense and survival in radiation-induced damage. In this article, we review the mechanisms underlying cellular responses to ionizing radiation and the role of Sirt1 in the process, with the aim of providing a theoretical basis for protection against radiation by Sirt1 as well as novel targets for developing radioprotective agents.

©2021 by Radiation Research Society. All rights of reproduction in any form reserved.
Haoren Qin, Heng Zhang, Shiwu Zhang, Siwei Zhu, and Hui Wang "Protective Effect of Sirt1 against Radiation-Induced Damage," Radiation Research 196(6), 647-657, (30 August 2021).
Received: 2 June 2020; Accepted: 11 August 2021; Published: 30 August 2021

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