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7 February 2022 Exosomes Participate in the Radiotherapy Resistance of Cancers
Dan He, Zhe Zhao, Bo Fu, Xiaofei Li, Long Zhao, Yongbin Chen, Lei Liu, Rui Liu, Jingyi Li
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Abstract

Radiotherapy is one of the main treatment modalities for cancer. However, some cancer patients will gradually develop resistance to radiotherapy, leading to tumor recurrence and metastasis. Radiation therapy usually promotes the secretion of exosomes from tumor cells and causes changes in their internal components. Accumulating evidence reveals that exosomes-mediated radiation-induced bystander effect (RIBE) is closely involved in radiotherapy resistance. In this article, we will discuss the relationship between exosomes and RIBE, highlight the effect of exosome components on resistance to radiation, and emphasize the role of exosome inclusion as a tumor biomarker for the prognosis of tumor treatment to develop new therapeutic approaches.

©2022 by Radiation Research Society. All rights of reproduction in any form reserved.
Dan He, Zhe Zhao, Bo Fu, Xiaofei Li, Long Zhao, Yongbin Chen, Lei Liu, Rui Liu, and Jingyi Li "Exosomes Participate in the Radiotherapy Resistance of Cancers," Radiation Research 197(5), 559-565, (7 February 2022). https://doi.org/10.1667/RADE-21-00115.1
Received: 6 June 2021; Accepted: 21 December 2021; Published: 7 February 2022
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