A study was carried out between August 2007 and January 2008 to determine the prevalence of helminth parasites of cane rats (Thryonomys swinderianus) and grey duikers (Sylvicapra grimmia) cropped from Asejire Game Reserve in Osun State, southwestern Nigeria. Totals of 93 and 13 faecal samples, respectively collected from cane rats and grey duikers, were examined for helminth parasites using sodium chloride floatation and zinc sulphate sedimentation methods. Of the 93 and 13 faecal samples examined from cane rats and grey duikers 78 (83.3%) and 7 (53.8%), respectively, were positive for helminth ova. For cane rats, Strongyle ova 71 (76.3%) was the most frequently observed followed by Strongyloides 38 (40.8%) Trichuris 33 (35.4%), Cestode 9 (9.6%) and Ascaris 5 (7.5%). For antelopes Strongyle ova 6 (46.0%) was also the most frequently encountered followed by Trichuris 4 (31.0%), Ascaris 2 (15.0%) and Cestode 1 (8.0%). Strongyloides ova were not detected in the faecal samples examined for grey duikers. No trematode ova were detected in any of the samples examined. Larvae of Haemonchus and Trichostrongylus were common to both cane rats and grey duikers faecal cultures. Cane rats carried greater worm burdens than grey duikers. The number of eggs per gram of faeces for Strongyle was the highest 390.6 ± 154.9 and 420.0 ± 1.0 for cane rats and grey duikers, respectively. We recommend health education for all the people concerned in handling the animals, including the consumers of bushmeat in whatever form.