We evaluated the efficacy of the biorational insecticides azadirachtin and spinetoram, as well as the neonicotinoid thiametoxam, the organophosphates chlorpyrifos and malathion, and the pyrethroid λ-cyhalothrin against the pepper weevil, Anthonomus eugenii Cano, in a field of jalapeño pepper, Capsicum annuum L., in South-Central Chihuahua. Thiametoxam and chlorpyrifos had an impact on the reduction of this pest as many as five days after application. Also, we evaluated the insecticide rotation effect of Treatment 1 (spinetoram → chlorpyrifos → chlorpyrifos → thiametoxam) and Treatment 2 (thiametoxam → chlorpyrifos → chlorpyrifos → thiametoxam) where both treatments suppressed populations of this insect. Treatment 1 had the fewest fallen fruits.