The prevalence of pediatric asthma in Zhengzhou District, China, was investigated by detecting serum mite specific IgE in patients. Blood samples collected from asthmatic children and non-asthmatic controls were analyzed for serum mite (Dermatophagoides farinae, Df) specific IgE (sIgE) levels by the UniCAP system. A total of 573 asthmatic children and 300 normal controls aged from 2 months to 13 years were recruited for this experiment. The positive rates of serum Df sIgE for three age groups of ∼3, ∼7, and ∼13-years were 31.4%, 63.7%, and 85.8%, respectively, and the total positive rate averaged 61.6%. In contrast, the total positive rate in non-asthmatic children was only 13.7% (P<0.01). The positive rates and levels of mite Df sIgE increased, but the frequency of higher Df sIgE levels decreased significantly with age in asthmatic children in Zhengzhou (P<0.005).