The genus Hexalobus consists of five species characterized by six basally fused petal lobes that are transversally folded in bud, which is unique within Annonaceae. The genus is widespread across tropical Africa occurring in rain forest, savanna, and woodland. The species H. callicarpus, occurring in Madagascar, is excluded from Hexalobus, so the genus is now restricted to continental Africa. The present revision provides a synthesis of previously published information and discussions on morphology, taxonomy, phylogeny, and palynology. Conservation status assessments are provided for each species, as well as a diagnostic key and detailed species descriptions. Furthermore, four species are illustrated and all species are mapped.