Five new natural hybrids of Lophiaris (Orchidaceae, Oncidiinae) are described and their accompanying illustrations provided. The five new nothospecies are: Lophiaris × cicyi (L. lurida × L. tapiae) from Campeche, Mexico, L. × lindeoerstedii (L. lindenii × L. oerstedii) from Quintana Roo, Mexico, L.×lurilindenii (L. lindenii×L. lurida) from Oaxaca, Mexico, L.×crispilurida (L. crispiflora×L. lurida) from Estelí, Nicaragua, and L.× lurigenensis (L. carthagenensis × L. lurida) from northern Venezuela. Comparisons of the floral characters of the new nothospecies and their putative parents are also illustrated with maps showing their corresponding geographical distributions. The etymology, distribution, ecology, informal conservation status, and comparative differences of the nothospecies with respect to their putative parental taxa have also been discussed. These characterizations will allow taxonomists to identify areas where isolation barriers break down and provide insight into the evolutionary processes that have complicated the understanding of the relationships among species and shaped relevantmorphological features of the flowers. We have also provided a comprehensive key to identify the Lophiaris species and their corresponding hybrids.