A new species of Galianthe from the west coast of Colombia and Ecuador that has fruits with indehiscent mericarps is described and illustrated. Galianthe holmneielsenii is most similar to Borreria ocymifolia and G. spicata, but differs in floral, fruit, and seed traits. An illustration of the diagnostic characters, a distribution map, information about the conservation status of the new species, and a key to the Galianthe species in Colombia and Ecuador are provided.