Natural history observations are presented for eight species of leaf-mining chrysomelid beetles. Oviposition habits are discussed for Chalepus bicolor (Olivier) and Chalepus walshii (Crotch). Leaf mines are described for C. walshii, Microrhopala xerene (Newman), Sumitrosis inaequalis (Weber), Dibolia chelones Parry, and Phyllotreta chalybeipennis (Crotch). Pnigalio flavipes (Ashmead) (Eulophidae) is reported as a parasitoid of D. chelones. Larvae of Mantura chrysanthemi (Koch) and Mantura floridana Crotch are compared. New larval host records include Calamagrostis canadensis (Michx.) and Elymus virginicus L. (Poaceae) for C. walshii; Doellingeria umbellata (Mill.) Nees (Asteraceae) for M. xerene; and Solidago flexicaulis L., Solidago patula Muhl. ex Willd., and Symphyotrichum puniceum (L.) Á. Löve and D. Löve (Asteraceae) for S. inaequalis.