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1 November 2002 Induction of Anti-Actin Drug Resistance in Tetrahymena
ROBERT V. ZACKROFF, LINDA A. HUFNAGEL
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Abstract

Both cytochalasin D and latrunculin B reversibly inhibited Tetrahymena phagocytosis at concentrations similar to those effective in mammalian systems, even though ciliate actins are known to be highly divergent from mammalian actins. Overnight exposure to relatively low (0.25 μM) concentrations of latrunculin B induced resistance in Tetrahymena to the inhibitory effects of that drug, as well as cross-resistance to cytochalasin D. However, much higher (>30 μM) concentrations of cytochalasin D were required for induction of cross-resistance to latrunculin B. Anti-actin drug resistance in Tetrahymena may involve a general multidrug resistance mechanism and/or specific feedback regulation of F-actin assembly and stability.

ROBERT V. ZACKROFF and LINDA A. HUFNAGEL "Induction of Anti-Actin Drug Resistance in Tetrahymena," The Journal of Eukaryotic Microbiology 49(6), 475-477, (1 November 2002). https://doi.org/10.1111/j.1550-7408.2002.tb00231.x
Received: 13 October 2001; Accepted: 9 September 2002; Published: 1 November 2002
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