Identification and Assignment of Function to the Genes of Aspergillus fumigatus Expressed at 37 °C

JATA SHANKAR; SHAILLY NIGAM; SHWETA SAXENA; TARUNA MADAN; P. USHA SARMA

doi:10.1111/j.1550-7408.2004.tb00390.x

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1 July 2004 Identification and Assignment of Function to the Genes of Aspergillus fumigatus Expressed at 37 °C

JATA SHANKAR, SHAILLY NIGAM, SHWETA SAXENA, TARUNA MADAN, P. USHA SARMA

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The J. of Eukaryotic Microbiology, 51(4):428-432 (2004). https://doi.org/10.1111/j.1550-7408.2004.tb00390.x

Abstract

Aspergillus fumigatus, a fungal pathogen, causes a spectrum of allergic and invasive disorders. In order to rapidly identify genes of this fungus relevant for pathogenesis and as potential antifungal drug targets, 125 expressed sequence tags (ESTs) were generated from 200 phage clones of a non-normalized cDNA library. Out of a novel 68 ESTs, 45 were assigned putative functions based on the sequence similarity. The identities of some of these genes suggest that they may be involved in pathogenesis or autoimmune reactions. Additional genes were identified that are possible targets for the development of antifungal drugs or that may be of use in diagnosing fungal infections.

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JATA SHANKAR, SHAILLY NIGAM, SHWETA SAXENA, TARUNA MADAN, and P. USHA SARMA "Identification and Assignment of Function to the Genes of Aspergillus fumigatus Expressed at 37 °C," The Journal of Eukaryotic Microbiology 51(4), 428-432, (1 July 2004). https://doi.org/10.1111/j.1550-7408.2004.tb00390.x

Received: 12 August 2003; Accepted: 17 April 2004; Published: 1 July 2004

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