Purple nutsedge is a troublesome weed in tomato grown in plasticulture systems. Field trials were conducted in the fall of 2017 and spring of 2018 at Balm, FL, to evaluate multiple herbicide programs applied pretransplanting (pre-T), post-transplanting (post-T), and pre-T followed by (fb) post-T for purple nutsedge control in plasticulture tomato. Pre-T treatment of sulfentrazone or S-metolachlor alone were ineffective and did not decrease purple nutsedge density compared with the nontreated control. Post-T application of halosulfuron did not reduce purple nutsedge density at 12 wk after initial treatment (WAIT) in fall 2017 but reduced the purple nutsedge density at 17 WAIT in both seasons. Pre-T sulfentrazone or S-metolachlor application fb halosulfuron applied post-T were the most effective treatments and consistently reduced purple nutsedge population in both seasons. Herbicide treatments did not injure or reduce tomato height or yield. Overall, these results suggest sequential herbicide programs, including pre-T application of sulfentrazone or S-metolachlor fb post-T application of halosulfuron generally resulted in greater purple nutsedge control compared with pre-T or post-T application only. Halosulfuron applied post-T is critical to provide season-long purple nutsedge control in plasticulture tomato.