Translator Disclaimer
1 February 2008 Comparison of the Antioxidant Activity of Albumin from Various Animal Species
Toshio Okazaki, Noriyuki Okudaira, Naohito Ishii, Hiroshi Yotsuyanagi, Toshiaki Nagai, Shougo Tokudome, Takahiro Fujioka, Shinichiro Takahashi
Author Affiliations +
Abstract

We measured the antioxidant activity of human, rat, bovine, rabbit, and guinea pig albumins against the superoxide, hydroxyl, and 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radicals. The albumins of different animal species did not differ in antioxidant activity against superoxide. Human and rat albumins exhibited antioxidant activity against hydroxyl radicals, but bovine, rabbit, and guinea pig albumins showed weaker antioxidant activity than human and rat albumins. Human, rat, rabbit, and guinea pig albumins, but not bovine albumin, exhibited strong antioxidant activity against DPPH radicals. Human and rat albumins with strong antioxidant activity against hydroxyl radicals contained methionine-123 in domain 1, but bovine, rabbit, and guinea pig albumins did not. Rat, rabbit, and guinea pig albumins with strong antioxidant activity against DPPH radicals had methionine-264 in domain 2. Human albumin did not have methionine-264, but methionine-298 and methionine-329 in domain 2. Bovine albumin, with the weakest antioxidant activity against DPPH radicals, contained no methionine residues in domain 2. These results suggest that methionine residues in domain 1 or 2 influence the antioxidant activity of albumin.

Toshio Okazaki, Noriyuki Okudaira, Naohito Ishii, Hiroshi Yotsuyanagi, Toshiaki Nagai, Shougo Tokudome, Takahiro Fujioka, and Shinichiro Takahashi "Comparison of the Antioxidant Activity of Albumin from Various Animal Species," Zoological Science 25(2), 172-177, (1 February 2008). https://doi.org/10.2108/zsj.25.172
Received: 11 May 2007; Accepted: 1 October 2007; Published: 1 February 2008
JOURNAL ARTICLE
6 PAGES


Share
SHARE
KEYWORDS
albumin
antioxidant activity
Cysteine
methionine
RIGHTS & PERMISSIONS
Get copyright permission
Back to Top