Three new species and a new genus of terrestrial gastropods are described from the Réserve naturelle des Nouragues in French Guiana. Cyclopedus anselini n. gen., n. sp. (forming new monotypical genus in the family Neocyclotidae Kobelt & Möllendorff, 1897) seems to be the smallest known cyclophoroid in the western hemisphere. The descriptions of the other two new species, Pseudosubulina theoripkeni n. sp. and P. nouraguensis n. sp., from the family Spiraxidae Baker, 1939, extend not only our knowledge of the geographical distribution of Pseudosubulina Strebel & Pfeffer, 1882 (previously known with certainty from Mexico only) but also the diagnosis of this genus, which now includes species with large penial stimulator and apertural dentition.