Centaurea khosraviana Negaresh sp. nova (Asteraceae) from West Azerbaijan Province, NW Iran, is described and illustrated. It is morphologically most similar to C. carduiformis subsp. orientalis, but differs from it by having a perennial habit, a loosely hirsute-articulate indumentum on the stem and leaves, fewer lateral segments of basal and lower cauline leaves, smaller involucres, a densely arachnoid indumentum on the phyllaries, narrower appendages, fewer cilia, and a shorter spine. In addition, the geographic distribution of the new species and closely related species is presented.