On the basis of a newly performed cladistic analysis the taxonomic concepts of Pedinina and its generic components are revised. Blindus and Colpotus are interpreted as subgenera of Pedinus, while Pedinulus and Vadalus are placed in synonymy with that name. Subgenera of Cabirutus are merged: (Cabirutus =Asiobirus syn. nov., =Dentibirus syn. nov.) Loensus (formerly Loensina) and Pseudopedinus (formerly incerte sedis) are transferred into the subtribe. In conclusion, Loensina is placed as a synonym of Pedinina. The following genera and subgenera are distinguished among Pedinina: Cabirutus (subgen. Cabirutus, Neocabirutus stat. nov.), Colpotinus, Loensus (subgen. Loensus, Pseudopedinus stat. nov.) and Pedinus (subgen. Blindus stat. rev., Colpotus stat. nov., Pedinus). An identification key to all genera and subgenera of the investigated subtribe is provided. Biogeographic patterns observed within Pedinina are briefly discussed. Loensus (Loensus) immaculatus is described as a new species. Pedinus infortunatus nom. nov. is proposed as a replacement name for Pedinus strigicollis Reitter, 1904, while Pedinus strigicollis Mulsant and Rey, 1853 for Pandarus strigosus Costa, 1847. A checklist of all species representing Pedinina is provided.