Immunization of Turkeys with a DNA Vaccine Expressing Either the F or N Gene of Avian Metapneumovirus

Darrell R. Kapczynski; Holly S. Sellers

doi:10.1637/7033

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1 October 2003 Immunization of Turkeys with a DNA Vaccine Expressing Either the F or N Gene of Avian Metapneumovirus

Darrell R. Kapczynski, Holly S. Sellers

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Avian Diseases, 47(4):1376-1383 (2003). https://doi.org/10.1637/7033

Abstract

SUMMARY. In this study we compared protection by DNA vaccination with the F (pCMV-F) or N (pCMV-N) gene from avian metapneumovirus (aMPV) in turkeys. One-week-old turkey poults received two intramuscular injections 2 wk apart. Birds were challenged with a turkey-embryo-adapted aMPV at 5 wk of age. Birds vaccinated with pCMV-F had decreased clinical signs of disease as well as significantly reduced virus load in tracheal swabs compared with birds vaccinated with pCMV-N or unvaccinated control birds. Serum neutralizing antibodies were significantly higher in birds receiving pCMV-F compared with all other groups. These results indicate that DNA vaccination with the F, but not N, gene of aMPV can induce significant protection against aMPV infection.

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Darrell R. Kapczynski and Holly S. Sellers "Immunization of Turkeys with a DNA Vaccine Expressing Either the F or N Gene of Avian Metapneumovirus," Avian Diseases 47(4), 1376-1383, (1 October 2003). https://doi.org/10.1637/7033

Received: 13 February 2003; Published: 1 October 2003

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