The pyrimidine herbicide aminocyclopyrachlor was evaluated for crop tolerance and weed control in wild blueberry (Vaccinium angustifolium Aiton). Preemergence applications of aminocyclopyrachlor at a rate of 50 g a.i. ha^-1 did not reduce aboveground blueberry biomass, yield potential, or final yield, and this rate appears safe for use in wild blueberry. Preemergence applications of aminocyclopyrachlor at a rate of 100 g a.i. ha^-1 reduced aboveground blueberry biomass, but yield potential and final yield were only reduced significantly at application rates of 200 and 400 g a.i. ha^-1. Preemergence applications of aminocyclopyrachlor at a rate of 100 g a.i. ha^-1 effectively suppressed Euthamia graminifolia (L.) Nutt., and further evaluation of aminocyclopyrachlor to identify safe application timings and rates in wild blueberry is warranted. Aminocyclopyrachlor applied as a directed spot spray provided good control of several herbaceous and woody perennial weeds, and this use pattern could provide an alternative management option for many perennial weeds in wild blueberry.