In an agroecosystem (AES), land-use types affect soil quality. As a result, determining soil quality in various land uses is critical. This study was carried out to evaluate the soil quality index (SQI) of the different land-use types in AESs of the Choke Mountain watershed, upper Blue Nile Basin. Forty-seven soil samples were taken from cultivated land (CL), grazing land (GL), plantation forest land (PFL), and natural forest land (NFL) of the five AESs. The minimum data set (MDS) was chosen using principal component analysis. To calculate SQI, five soil quality indicators were selected as an MDS: silt, pH, cation exchange capacity, exchangeable potassium, and soil organic matter. SQIs for the overall land uses were ordered as GL > NFL > PFL > CL. Compared with NFL, the SQIs of PFL and CL were reduced by 10% and 19.7%, respectively, whereas the SQI of GL was increased by 1.8%. Among AESs of Choke, SQI of GL was higher in the midland plain, dominated by Vertisol (AES 2), followed by the midland plain with Nitosols (AES 3). SQI of CL was intermediate, and SQIs of GL, NFL, and PFL were good. AES 2 of the watershed recorded the highest total SQI value, whereas hilly and mountainous highlands (AES 5) recorded the lowest SQIs compared to other AESs. Thus, site-specific land use and management practices across the various AESs should be recommended to policymakers and farmers for a sustainable ecosystem and environment.