We observed evidence of predation on freshwater mussels during a field experiment. Mussels within the stream reach and experimental enclosures were dislodged from the sediment and shells were crushed whole, and the substrate and enclosures were extensively disturbed. Of the 12 mussel species detected in pre-experiment sampling, a Jacob's electivity index suggested that only two species (Fusconaia cerina and Elliptio arca) were positively selected for by the predator, with F. cerina being strongly preferred; other dominant species were avoided. We estimated that 1% of the mussel community and 6% of the F. cerina population was predated. We found that 70% of the experimental enclosures were disturbed, but those containing F. cerina were disturbed at a higher rate than other treatments. Water depth was a significant factor predicting disturbance of enclosures, and disturbance was not as severe for enclosures in deeper water. Based on characteristics of the event, we suggest that feral pigs (Sus scrofa) were responsible for the predation and disturbance. While only a small portion of the mussel community was predated, continued species and spatial selection could shift community structure and distribution. Feral pigs also may pose an indirect threat to mussel populations because substrate disturbance by rooting could decrease sediment stability.