Downy brome (Bromus tectorum L.) is a highly invasive winter annual grass that can fill open niches in native plant communities. Prescribed burning is often used to control B. tectorum and can be combined with herbicide treatments to extend the duration of control and promote the native plant community. Several herbicides have been evaluated in conjunction with burning for B. tectorum control, although the herbicide indaziflam has not. In September 2017, two B. tectorum–infested sites were burned in Colorado foothill shrublands. In March 2018, indaziflam was applied alone or in combination with glyphosate, rimsulfuron, or imazapic. These treatments were compared with imazapic plus glyphosate as a standard. All treatments were made within burned and non-burned areas in a crossed-nested design. Bromus tectorum cover and the desirable plant community responses were evaluated 1 and 2 yr after treatment (YAT). In non-burned areas, all indaziflam treatments reduced B. tectorum cover compared with the control. In contrast, reductions from the imazapic treatments did not persist after the first year. Most post-burn treatments further decreased B. tectorum cover compared with the non-burned treatments. The most effective treatments (indaziflam 44 and 73 g ai ha^–1 + imazapic 123 g ae ha^–1) provided similar levels of control (<1% B. tectorum cover at 2 YAT), with or without burning. Desirable plant cover, richness, and diversity were not negatively impacted by burning or herbicide treatments. Plant diversity and species richness increased at Site 2 when burning was followed by indaziflam treatments. This study indicates that B. tectorum control using indaziflam can be enhanced when applied after burning, and the combinations with imazapic or rimsulfuron provide a wider application window compared with the combination with glyphosate.