Bathymodiolamides C, D, and E, Necrosis Inducers from a Deep-Sea Hydrothermal Vent Invertebrate Mussel, Bathymodiolus azoricus

Eric H. Andrianasolo; Liti Haramaty; Kerry L. Mcphail; Richard A. Lutz

doi:10.2983/035.042.0201

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Eric H. Andrianasolo,^1,2,* Liti Haramaty,³ Kerry L. Mcphail,⁴ Richard A. Lutz³

¹Centre National de Recherches Industrielle et Technologique (CNRIT), 38, rue Rasamimanana, Fiadanana, Antananarivo, 101, Madagascar
²University of Waterloo, Biology Department, 200 University Ave W, Waterloo, Ontario, N2L3G1, Canada
³Department of Marine and Coastal Sciences, Rutgers, The State University of New Jersey, 71 Dudley Road, New Brunswick, NJ 08901-8521, USA
⁴Department of Pharmaceutical Sciences, Oregon State University, 103 SW Memorial Place, Corvallis,OR 97331, USA

^*Corresponding author. E-mail: eric.andrianasolo@uwaterloo.ca

Abstract

Three ceramides with intriguing structural features, bathymodiolamides C (1), D (2), and E (3), were isolated from the deep-sea hydrothermal vent invertebrate mussel Bathymodiolus azoricus that inhabits vent environments along the Mid-Atlantic Ridge. The molecular structures of these compounds were elucidated using a combination of Nuclear Magnetic Resonance spectroscopy, mass spectrometry, and chemical degradation. Biological activities were assessed by Lactate Dehydrogenase assay for necrosis induction and the patented ApopScreen cell-based screen for apoptosis-induction and potential anticancer activity. This represents a second report of ceramide natural products from B. azoricus.

Citation Download Citation

Eric H. Andrianasolo, Liti Haramaty, Kerry L. Mcphail, and Richard A. Lutz "Bathymodiolamides C, D, and E, Necrosis Inducers from a Deep-Sea Hydrothermal Vent Invertebrate Mussel, Bathymodiolus azoricus," Journal of Shellfish Research 42(2), 177-197, (8 September 2023). https://doi.org/10.2983/035.042.0201

Published: 8 September 2023

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