The protohistoric period in North America is broadly characterized by transformations in indigenous lifeways. Excavations during the summer of 2015 at BgDs-25, a small shell-bearing site in the northern Quoddy Region of southwest New Brunswick, Canada, present a strong case for continuity as well as change. Some of the archaeological materials from BgDs-25, including faunal remains, lithic technology, and settlement structure, share commonalities with earlier Quoddy Region Maritime Woodland period assemblages. In conjunction with other work in this area, however, the BgDs-25 results also suggest important shifts took place in settlement, subsistence, and lithic technology during the late 16th and early 17th centuries. These shifts may have been a response to the arrival of Europeans, but may have also extended processes of change that had their initiation in the earlier Maritime Woodland period.