We identified a malignant lymphoma infiltrating the lung, liver, kidney, mesenteric lymph nodes, and eye as the cause of death in a male West Indian manatee (Trichechus manatus). Diagnosis was based on gross, histopathologic, and immunohistochemical studies. Tissue samples from ten organs were included in a tissue microarray and sections from this array were subjected to immunohistochemical staining. The cytoplasm of the neoplastic lymphocytes identified in six organs was positive for CD3, a marker for T-cell differentiation. The neoplastic cells were negative for CD79a, a marker for B-cell differentiation. The cause of this neoplasm was not determined. This is the first report of malignant lymphoma in the mammal order Sirenia.
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1 October 2005
Malignant Lymphoma in a West Indian Manatee (Trichechus manatus)
Anne S. Hammer,
Bjarne Klausen,
Steffen Knold,
Hans H. Dietz,
Stephen J. Hamilton Dutoit
Journal of Wildlife Diseases
Vol. 41 • No. 4
October 2005
Vol. 41 • No. 4
October 2005
case history
lymphoma
Tissue microarray
Trichechus manatus
West Indian manatee