It is long past the time when we should be recognizing that the potential impacts of animal health interventions focused on livestock may in fact be far from environmentally benign. “First, do no harm” must apply to animal health policy-making as much as these wise words apply to clinical practice. An effort to assess the Global Burden of Animal Diseases, analogous to a long-standing and highly regarded endeavor in the public health realm, has only just been recently announced. This development offers an important opportunity for the formulation of data-driven policy guidance in support of holistic animal health and land-use management decisions that are more likely to be socially, ecologically, and economically sustainable for generations to come.