A 5-yr-old female Egyptian fruit bat (Rousettus aegyptiacus) had a small raised pigmented mass removed from the lateral canthus of the left eye. Six additional variably sized, raised, smooth to cauliflower-like skin masses were observed randomly distributed throughout the left wing membranes. Four masses were removed and diagnosed microscopically as basosquamous carcinomas and papillomas. Additional masses, removed 6 mo and 1 yr later, showed bony invasion and squamous differentiation. Immunohistochemistry detected positive intranuclear staining for bovine papillomavirus antibody in all samples. Polymerase chain reaction done on DNA extracts from formalin-fixed, paraffin-embedded tumor tissue amplified a 450 base-pair segment analogous to the L1 region of human papillomavirus types 96 and 5. Basic Local Alignment Search Tool analysis of sequenced amplicons suggests a novel chiropteran papillomavirus. To our knowledge, this is the first report of papillomavirus-associated carcinoma in a chiropteran species.
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1 June 2006
PAPILLOMAVIRUS-ASSOCIATED BASOSQUAMOUS CARCINOMA IN AN EGYPTIAN FRUIT BAT (ROUSETTUS AEGYPTIACUS)
Christy A. McKnight,
Annabel G. Wise,
Roger K. Maes,
Christopher Howe,
Annabel Rector,
Marc Van Ranst,
Matti Kiupel
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Journal of Zoo and Wildlife Medicine
Vol. 37 • No. 2
June 2006
Vol. 37 • No. 2
June 2006
carcinoma
Chiroptera
Egyptian fruit bat
papillomavirus
Rousettus aegyptiacus