Chemical immobilization of wildlife, required for many biological studies and management events, often induces hypoxemia and respiratory depression. Laryngeal mask airways (LMAs) have shown promise as an efficient method of airway protection during anesthesia. Nineteen wild bighorn sheep (Ovis canadensis) lambs were immobilized using an IM combination of medetomidine (0.16 ± 0.062 mg/kg), azaperone (0.20 ± 0.058 mg/kg), and alfaxalone (0.54 ± 0.21 mg/kg) via remote injection. Upon recumbency, arterial blood gas parameters, minute ventilation (V_E), tidal volume (V_T), and respiratory rate were measured before and after LMA placement. The V_E and V_T were measured via respirometer. Time to LMA placement, cuff pressure, cuff volume, and ease of placement were measured. Medetomidine was reversed with IM atipamezole at five times the medetomidine dose upon completion of procedures. Pre- and post-LMA measurements were compared using a t test or a Wilcoxon signed-rank test based on normality of the data. The LMA provided a patent airway in all lambs with a significant (P < 0.0001) increase in VE (mean [95% CI]; pre-LMA: V_E = 17.3 [16.2–18.5] L/min, post-LMA: V_E = 19.8 [18.6–21.0] L/min) but did not have a significant impact on partial pressure of oxygen (PaO₂; pre-LMA: corrected PaO₂ = 45.2 [41.2–49.2] mm Hg, post-LMA: corrected PaO₂ = 47.5 [43.3–51.7] mm Hg; P = 0.19) or partial pressure of carbon dioxide (PaCO₂; pre-LMA: PaCO₂ = 50.4 [46.6–53.2] mm Hg, post-LMA: PaCO₂ = 51.6 [48.8–55.7] mm Hg; P = 0.035) following placement. This study demonstrated that the LMA is a viable option for airway protection in wild bighorn sheep.