The new species Cestrum sotonunezii Mont.-Castro (Solanaceae) is described from central Mexico. Because of their overall similarity, specimens of the new species have been previously confused with C. flavescens Greenm., C. aurantiacum Lindl., C. oblongifolium Schltdl., and C. thyrsoideum Kunth, all of which also occur in central Mexico. The new species is most similar to C. flavescens, but is clearly separated by several characteristics, mainly differences in the androecium. The new species is described and illustrated, and a key to distinguish morphologically similar species in central Mexico (Guerrero, Michoacán) is provided.