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2 September 2016 Modeling of Irradiated Cell Transformation: Dose- and Time-Dependent Effects
Ludwik Dobrzyński, Krzysztof W. Fornalski, Yehoshua Socol, Joanna M. Reszczyńska
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Abstract

We report here on various biophysical aspects of irradiated cells, beginning with a phenomenological description of radiation-induced cancer cells. This description includes detrimental factors such as chromosomal aberrations, as well as beneficial factors, such as adaptive response. Also discussed here is the dose- and time-dependent evolution of cancer cells using a purely mathematical approach. The general dose-response shape, which is sigmoidal, is shown to be modified by such mechanisms as adaptive response or bystander effect. The many aspects of the sigmoid function, which most appropriately demonstrates the relationships among irradiated organisms, are discussed here as well. Finally, the balance equation is presented as the most general relationship for irradiated cell behavior.

©2016 by Radiation Research Society
Ludwik Dobrzyński, Krzysztof W. Fornalski, Yehoshua Socol, and Joanna M. Reszczyńska "Modeling of Irradiated Cell Transformation: Dose- and Time-Dependent Effects," Radiation Research 186(4), 396-406, (2 September 2016). https://doi.org/10.1667/RR14302.1
Received: 27 October 2015; Accepted: 1 July 2016; Published: 2 September 2016
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