There were a total of 12 documented Panax quinquefolius (American Ginseng) in the only known population in Louisiana in 1986. Our reassessment of the population in 2016 found 16 plants. We suggest that the long-term persistence of this tiny American Ginseng population indicates that simple matrix-population models may be overestimating quasi-extinction numbers and minimum viable populations, perhaps as a result of failing to sufficiently consider influences of environmental conditions. We further suggest that this, the southernmost documented population of the species in the US, has endured beyond expectation but remains at acute risk of extirpation and that any population-specific genes are at risk of loss if no intervention is made to protect the population.