Zebra chip disease has become a serious problem in North America. Data from growers in Kansas, Nebraska, and Texas enabled us to document insecticide use and costs to control zebra chip in 53 commercial fields of potato, Solanum tuberosum L. The number of different insecticides used in Texas decreased from 16 in 2009 to 10 in 2011. The most commonly used insecticides in all three states were Admire (imidacloprid) and Movento (spirotetramat). Growers in Texas spent an average of $740 per hectare annually during 2009–2011, while those in Kansas and Nebraska spent $700 per hectare. Costs varied among fields in the same locations. Issues raised by this study included: insecticide use progression, control of other insects, yield loss, quality loss, strategies to manage zebra chip, and the impact of zebra chip on the competitive positions of potatogrowing areas.