An essential element of science instruction is content literacy. In order to improve literacy specific to science, vocabulary must be addressed. As jitendra et al. (2004) pointed out, “because learning vocabulary during independent reading is very inefficient for students with reading difficulties, vocabulary and word learning skills must be taught.” We provide a summary of an investigation to improve the technology-based vocabulary of students with learning disabilities in a freshman high school biology class. The procedures for the project are provided, along with lessons learned about vocabulary instruction of students with disabilities.