Human–wildlife conflict presents major challenges to both wildlife managers and rural livelihoods. Here, we investigated human–wildlife conflict in and around Senkele Swayne's Hartebeest Sanctuary (SSHS). We estimated the densities of wild animals within SSHS and conducted questionnaire interviews about livestock predation and crop raiding patterns with individuals in 378 households occurring <3000 m outside the Sanctuary's borders. Respondents reported that hyenas Crocuta crocuta and African wolves Canis anthus were the only livestock predators and were responsible for combined losses of ∼ 10% (29 207 USD) of their livestock over a three-year period. Hyenas predated cattle, goats, sheep, donkeys and horses, whereas African wolves targeted only goats and sheep. Hyena predation occurred both inside and outside SSHS, whereas African wolf predation occurred mainly near the inside periphery of the sanctuary. Most (58%) of the respondents experienced crop raiding of their farms by Swayne's hartebeest Alcelaphus buselaphus swaynei, warthogs Phacochoerus africanus and/or crested porcupines Hystrix cristata. Nearly two-thirds (64%) of the crop raiding occurred 1–1500 m from the sanctuary. Potatoes and maize were the most commonly raided crops. Local communities used guarding, patrolling, loud noises, smoky fires, flashes of light, fences and trenches as deterrence methods. Of the crop raiding species, only Swayne's hartebeests were regarded positively, while warthogs and crusted porcupines were viewed negatively by respondents. We conclude that although SSHS is of critical conservation value to the Swayne's hartebeest, the surrounding communities endure significant livestock predation and crop raiding by wild animals sheltered in the sanctuary. The survival of this relict population of Swayne's hartebeest in the sanctuary remains at risk unless the human–wildlife conflict in surrounding areas is resolved. This calls for site-specific measures in consultation with the local community.