Oral Vaccination of Skunks with Raccoon Poxvirus Recombinants Expressing the Rabies Glycoprotein or the Nucleoprotein

Makonnen Fekadu; John H. Shaddock; John W. Sumner; Dane W. Sanderlin; Janice C. Knight; Joseph J. Esposito; George M. Baer

doi:10.7589/0090-3558-27.4.681

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1 October 1991 Oral Vaccination of Skunks with Raccoon Poxvirus Recombinants Expressing the Rabies Glycoprotein or the Nucleoprotein

Makonnen Fekadu, John H. Shaddock, John W. Sumner, Dane W. Sanderlin, Janice C. Knight, Joseph J. Esposito, George M. Baer

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J. of Wildlife Diseases, 27(4):681-684 (1991). https://doi.org/10.7589/0090-3558-27.4.681

Abstract

Twenty nine skunks (Mephitis mephitis) were vaccinated orally with raccoon poxvirus (RCN) recombinants: 10 with a recombinant expressing the rabies virus glycoprotein (RCNRG), 10 with RCNRG mixed with a recombinant expressing the rabies virus nucleoprotein (RCNRN) and nine with RCN alone. Rabies virus neutralizing antibodies were detected in six of the 20 skunks; five skunks (three given RCNRG, two given a mixture of recombinants) survived a rabies challenge that was lethal for nine skunks vaccinated with RCN alone.

Fekadu, Shaddock, Sumner, Sanderlin, Knight, Esposito, and Baer: Oral Vaccination of Skunks with Raccoon Poxvirus Recombinants Expressing the Rabies Glycoprotein or the Nucleoprotein

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Makonnen Fekadu, John H. Shaddock, John W. Sumner, Dane W. Sanderlin, Janice C. Knight, Joseph J. Esposito, and George M. Baer "Oral Vaccination of Skunks with Raccoon Poxvirus Recombinants Expressing the Rabies Glycoprotein or the Nucleoprotein," Journal of Wildlife Diseases 27(4), 681-684, (1 October 1991). https://doi.org/10.7589/0090-3558-27.4.681

Received: 27 August 1990; Published: 1 October 1991

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