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11 June 2021 TERBINAFINE PHARMACOKINETICS FOLLOWING SINGLE-DOSE ORAL ADMINISTRATION IN RED-EARED SLIDER TURTLES (TRACHEMYS SCRIPTA ELEGANS): A PILOT STUDY
David Eshar, Butch KuKanich, Nili Avni-Magen, Hyun Joo
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Abstract

In this pilot study, the pharmacokinetics of terbinafine were determined in six apparently healthy red-eared slider turtles (Trachemys scripta elegans) after a single PO administration. Terbinafine suspension (15 mg/kg, once) was administered via gavage tube to all turtles. Blood samples were collected immediately before (time 0) and at 1, 2, 4, 8, 24, and 48 h after drug administration. Plasma terbinafine concentrations were quantified by ultra-performance liquid chromatography–mass spectrometry, and noncompartmental pharmacokinetic analysis was performed. None of the animals showed any adverse responses following terbinafine administration. Mean area under the curve from time 0 to 24 h was 1,213 h × ng/ml (range 319–7,309), mean peak plasma concentration was 201.5 ng/ml (range 45.8–585.3), mean time to maximum plasma concentration was 1.26 h (range 1–4), mean residence time was 7.71 h (range 3.85–14.8), and mean terminal half-life was 5.35 h (range 2.67–9.83). The administration of terbinafine (15 mg/kg, PO) may be appropriate for treatment of select fungal organisms with low minimum inhibitory concentrations in red-eared slider turtles but may require q12h administration even for organisms with low minimum inhibitory concentrations. Multiple-dose studies as well as clinical studies are needed to determine ideal dosages and efficacy.

Copyright 2021 by American Association of Zoo Veterinarians
David Eshar, Butch KuKanich, Nili Avni-Magen, and Hyun Joo "TERBINAFINE PHARMACOKINETICS FOLLOWING SINGLE-DOSE ORAL ADMINISTRATION IN RED-EARED SLIDER TURTLES (TRACHEMYS SCRIPTA ELEGANS): A PILOT STUDY," Journal of Zoo and Wildlife Medicine 52(2), 520-528, (11 June 2021). https://doi.org/10.1638/2020-0079
Accepted: 18 January 2021; Published: 11 June 2021
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