The sagebrush biome is rapidly deteriorating largely due to the ecosystem threats of conifer expansion, more frequent and larger wildfires, and proliferation of invasive annual grasses. Reversing the impacts of these threats is a formidable challenge. The Sagebrush Conservation Design (SCD) emphasized that limited conservation resources should first be used to maintain Core Sagebrush Areas (CSA), and then to grow such areas where possible. The SCD heightens the ecological importance of maintaining and strategically growing CSAs. However, the fact that these areas have been identified does not mean that conservation is immediately possible or will be effective. Strategic conservation in the sagebrush biome does not only involve working in ecologically important areas; it is an approach that must explicitly acknowledge the social and administrative conditions in which individuals and organizations are making decisions. We accordingly propose that strategic, durable work can only occur in geographies of “conservation readiness,” that is, where ecological importance, social capacity, and conducive administrative conditions intersect. We offer a framework for assessing conservation readiness that functions as both an inventory and diagnostic tool, highlighting current assets while shining a light on needs and the types of activities that will create or sustain conservation readiness. We demonstrate the utility of the Conservation Readiness Framework for identifying the different roles and activities that must occur at local, mid, and regional levels to nurture conservation readiness over time. In practice, this approach contrasts with management driven solely by ecological importance and illustrates that effective conservation must also involve targeted efforts that curate both social and administrative conditions.