Creating partnerships that leverage skill sets from universities and corporate entities to improve STEM (science, technology, engineering, and mathematics) education is often discussed in theory. However, examples of successful models that might inform practice are scarce. This article describes how one STEM business, university educators, and middle school administrators and teachers successfully developed and implemented an integrated STEM education (iSTEM) experience for all eighth-grade students at a local middle school. We created a professional learning community to establish the goals and vision for the iSTEM day, which included the use of instructionally sound pedagogical methods, intellectually stimulating learning experiences, and a deeply developed understanding of the school context. Our team successfully completed a one-day learning experience that focused on the fundamental concept of osmosis and problem-solving skills. However, the broader impacts of this day included a new collaborative network between the university, the company, and the middle school that remains intact and productive.