We designed a course based on inquiry learning using WISE, an online inquiry-based science environment platform, and the 5E instructional model. This article summarizes guidelines used in designing the course, analyses of student needs and school environment, setting of course objectives, modification of materials, and evaluation of student performance. A “Healthy Life” course based on those guidelines was implemented, along with a teacher-training workshop, in two schools, and pretests and posttests were administered to evaluate the achievements of the project participants. The results showed that the participants had constructed scientific concepts and improved their level of cognitive knowledge. An efficiency questionnaire and semistructured interviews demonstrated the effectiveness of the course, thus indicating that we should share the guidelines and features of the Healthy Life course with other course designers and teachers.