Hyphodermella aurantiaca C.L. Zhao sp. nova (Polyporales, Basidiomycota) is described based on morphological and molecular evidence. The species has an annual growth habit, resupinate basidiomata with saffron to orange hymenial surface, a monomitic hyphal system with generative hyphae bearing simple septa, IKI–, CB–, and ellipsoid, hyaline, thin-walled, smooth, IKI–, CB– basidiospores. In phylogenetic analyses based on molecular data of ITS + nLSU and nLSU sequences H. aurantiaca formed a monophyletic lineage with a strong support (100% BS, 100% BP, 1.00 BPP) and grouped with H. corrugata, H. poroides and H. rosae.